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KMID : 0613820080180010023
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Journal of Life Science
2008 Volume.18 No. 1 p.23 ~ p.29
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Ginsenosides Protect the High Glucose-induced Stimulation of IGFs in Mesangial Cells
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Bae Chun-Sik
Lim Do-Seon
Yoon Byung-Cheol
Jeong Moon-Jin
Yoon Kyung-Chul
Park Su-Hyeon
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Abstract
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Panax ginseng C. A. MEYER is one of the most widely used herbal medicines in the Asian countries and has diverse functions including anti-diabetic action. The dysfunctions of mesangial cells in hyperglycemic conditions are implicated in the development of diabetic nephropathy. Insulin-like growth factors (IGFs) are also associated with the onset of diabetic nephropathy. Thus, we examined the effect of ginsenosides against high glucose-induced dysfunction of primary cultured rat mesangial cells. In the present study, high glucose increased IGF-I and IGF-II secretion in mesangial cells. Ginsenoside total saponin (GTS) prevented high glucose-induced increase of IGF-I and IGF-II secretion in mesangial cells. In addition, GTS prevented high glucose-induced increase of lipid peroxide formation and decrease of GSH contents. GTS also ameliorates high glucose-induced increase of arachidonic acid release and decrease of prostaglandin . In conclusion, GTS prevented high glucose-induced dysfunction of mesangial cells via inhibition of oxidative stress and arachidonic acid pathways.
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KEYWORD
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Ginsensides, mesangial cells, high glucose, diabetic nephropathy, insulin-like growth factor-1
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